Laboratory Medicine
Test Directory / Diabetes Autoantibodies
Diabetes Autoantibodies
Brown clotted serum, gel barrier
| Test | Diabetes Autoantibodies |
|---|---|
| Common Abbreviations | DAA/ GAD/ IA2/ ZnT8 |
| Profile | Anti-Tyrosine phosphatase-like insulinoma antigen 2 (IA-2/IA2) antibodies Zinc Transporter 8 (ZnT8) islet autoantibodies Glutamic Acid Decarboxylase (GAD) antibodies |
| Clinical Indication | Autoantibodies recognising the islet cell antigens glutamic acid decarboxylase (GAD 65), Zinc Transporter 8 (ZnT8) and the anti-tyrosine phosphatase-like insulinoma antigen 2 (IA-2) are present in up to 90% of newly diagnosed patients with type 1 diabetes. The prevalence of GAD, IA-2 and ZnT8 autoantibodies is less than 1% in GCK, HNF1A and HNF4A MODY, and testing for these autoantibodies close to diagnosis gives very good discrimination of Type 1 diabetes from MODY (McDonald et al 2011 Diabet Med 28:1028-1033) |
| Specimen Type | Blood |
| Sample Type | Serum |
| Minimum Volume | 0.5ml |
| Special Precautions | No special requirements |
| Stability | Contact referral laboratory |
| Turnaround Time | 3 weeks |
| Laboratory | Area A2. Royal Devon & Exeter NHS Foundation Trust, Barrack Road, Exeter. EX2 5DW |
| Reference Interval | Contact referral laboratory |
| Limitations | Contact referral laboratory |
