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Laboratory Medicine

Test Directory / Protein/Creatinine Ratio

Protein/Creatinine Ratio

Urine monovette, white topped universal or 24 hour container (no additives)

TestProtein/Creatinine Ratio
Common AbbreviationsPCR
ProfileNA
Tube typeUrine monovette, white topped universal (no additives)
Clinical IndicationProteinuria is an important indicator of the onset and progression of kidney disease. Increased levels of urinary protein may also be present following strenous exercise or in monoclonal gammopathies and urinary tract infections. Protein:creatinine ratio, and not microalbumin: creatinine ratio, should be requested in pregnancy and where non-albumin proteinuria is suspected.
Specimen TypeUrine - early morning, mid-stream urine preferred
Sample typeRandom
Minimum Volume1mL
Special PrecautionsNo special requirements
Stability48 hours at 2-4oC
Turnaround TimeInpatient: 6 hours Outpatient/ GP: 24 hours
LaboratoryYork and Scarborough
Reference Interval<30mg/mmol in pregnancy. Otherwise, please refer to NICE GC 182 (CKD).
LimitationsSamples contaminated by haemoglobin may give falsely elevated levels. Analysis of urine samples containing immunoglobulin light chains (i.e. Bence-Jones Protein) may result in the underestimation of protein. Discrepancies may also arise in samples from patients being treated with polypeptide based plasma substitutes which may be excreted in the urine thereby giving very high results.
Notes
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Incident at York Hospital

Please be aware that the internal access road to the Blue Badge car park at the front of York Hospital is temporarily closed following a road traffic incident. As a result, drop-off and collection at the main entrance, along with access to Blue Badge parking in that area, is currently unavailable. Pedestrian access is unaffected.

Access to all other areas of the hospital site remains open, including the multi-storey car park, where disabled parking is available.

We’re asking patients and visitors to plan ahead, as traffic flow into the site is busier than usual. Thank you for your patience and understanding.